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DeNovo® NT Natural Tissue Graft
Surgical Techniques
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Techniques PDF

DeNovo® NT Natural Tissue Graft Surgical Technique

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DeNovo® NT Natural Tissue Graft Surgical Technique: Biologic treatment for early prevention and cartilage repair

DeNovo NT Natural Tissue Graft
Product Description

DeNovo NT Natural Tissue Graft is a juvenile cartilage allograft tissue intended to provide surgeons with an early-intervention option for the repair of articular cartilage in a wide range of anatomic focal cartilage defects. It offers a single-stage procedure with fibrin fixation that eliminates the need for harvesting a periosteal flap. 

Juvenile Cartilage Tissue
DeNovo NT Graft consists of particulated natural articular cartilage with living cells. The tissues are recovered from juvenile donor joints.

Single-Stage Procedure with Fibrin Adhesive

  • Simplified surgical technique
  • No need to harvest and sew a periosteal flap
  • No donor site morbidity

Pre-clinical Evidence*
Demonstrated in equine trochlea model at six months post-implantation1:

  • Defect filling with a continuous volume of cartilage repair tissue after implantation of particulated cartilage tissue pieces
  • Minimal subchondral bone resorption
  • No indication of tissue rejection/inflammation

Clinical Experience

  • Human clinical experience to date includes greater than three years of implant history
  • DeNovo NT Graft has been used to treat focal articular defects in a wide range of anatomical applications (knee, ankle, hip, shoulder, elbow, great toe)
  • DeNovo NT Natural Tissue Graft, a human tissue allograft, is an available cartilage repair treatment in the United States. DeNovo ET Engineered Tissue Graft is undergoing a clinical study as an investigational biological product, and is limited by US law to investigational use

*Animal study results are not necessarily predictive of human clinical results.

References
  1. Frisbie et al. Data on file at ISTO Technologies, Inc.